Wobble uridine modifications–a reason to live, a reason to die?!

Wobble uridine modifications–a reason to live, a reason to die?!

Wobble uridines (U34) are generally modified in all species. U34 modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecular machinery required to introduce these modifications into tRNA posttranscript...

Learning to Reason: a Reason!-able Approach

How are general informal reasoning skills acquired? Little research has been done on this topic. Two hypotheses dominate. According to the strong situated learning hypothesis, there are no general informal reasoning skills (only contextor domainspecific skills) and so nothing can be done to improve them. According to the practice hypothesis, general informal reasoning can be improved through in...

A Reason to Add Registers

The increasing gap between CPU and memory performance forces us to reevaluate design choices made in the past to optimize the CPU-memory interface. Ideally, all CPU operand traffic would remain on-chip. It is obviously not feasible to have the number of registers be on the order of main memory size and it is not clear that increasing L1 cache sizes has significant benefit.[10] Current instructi...

Vision to reason

How to Reason Defeasibly

This paper describes the construction of a general-purpose defeasible reasoner that is complete for first-order logic and provably adequate for the argument-based conception of defeasible reasoning that I have developed elsewhere. Because the set of warranted conclusions for a defeasible reasoner will not generally be recursively enumerable, a defeasible reasoner based upon a rich logic like th...